The girl with the ponytail is definitely Lesnick's work. The kid with the weird glasses is from Anti-Hero for Hire, from the maker of Adventurers.

That being said, I think the comic is rather harsh. Like you said, it mocks webcomics in general. I read it and I hear, 'all webcomics suck except Achewood'. Telling that to a public that probably reads a -lot- of webcomics might raise the geek equivalent of fire and pitchforks.