There is no doubt about it, people who really enjoy Achewood are a rare kind of awesome and...
You're generally gonna find they're otherwise into awesome and/or weird things, too.
You're going to have to explain that it is a strip specifically created in overseas factories for the sole purpose of entertaining sick fucks and hot nerd-girls. Hopefully, this will trap the offending lady into saying something like: "But I'm a hot nerd-girl and I don't like it!"
And then you can stare at her for a second, causing her to realize that you are either pointing out that she is not hot or is not a nerd, whichever of those things would offend her most.
If she is hot but not a nerd, she will be offended that you are calling her less than hot. If she is a nerd, she will be offended that you are calling her not a nerd. If she is neither, she will think you're claiming she has a c*ck but... when she flashes you her pu$$y, it really won't be that awesome because she's clearly not a hot nerd-girl.
In any case, you have called her on the fact that... as she is not into Achewood, there is a ceiling to how awesome of a person she could actually be.
People are offended by how awesome people into Achewood are, you see.
It is disrespectful to their lesser level of awesomeness. Being into Achewood is totally Rude.