Being the sober one in a group of drunk people is hilarious if and only if your friends are all good/funny drunks. In college, it was occasionally a raging asspain because someone who was a bad drunk would decide to tie one on and spoil everyone's fun. I had one friend, normally a very bright and interesting person, who would get stressed and descend into the most obnoxious drinking m.o. imaginable:
1) Arrange to get drunk much more quickly than anyone else at the party (for example, by bringing and drinking a bottle of homemade screwdrivers at a wine-and-cheese social)
2) Once thoroughly drunk, start hitting on inappropriate people: those of genders/orientations that didn't align with hers, incredibly awkward people, people in relationships, or as many combinations of the above as possible
3) At some point, just start having a psychotic episode (at the wine-and-cheese social, it was screaming)
This meant that any party where she played this trick turned quickly into, to reuse a phrase, damaged-person wrangling, and the brunt of it always fell to the sober. Not cool.
(This is before we get onto the subject of mass hysteria, i.e. "Hey guys! It's 2 AM and we're all drunk! Let's walk to the Green River and go skinny-dipping! How can this go wrong?!")