I did almost perfect instead of nuke anomaly. I also like the mask because it doesn't break down, which is sorta nice. I also like the way it looks, although I don't see my guy much. IIRC, he has pink hair and a beard. I'm not usually a power armor guy, either, because of the penalties.
Hate hate hate overlords. I'd played it a lot before I got the GOTY edition, and all of a sudden 'hey, instant death over and over!' I also have problems with the searching when the folks explode. Actually, I have problems with searching even without that, sometimes - trying to find the sweet spot to pick things up and suchlike.
I'm not a fan of swift learner, because I didn't need any help getting leveled up, plus sleeping gives you +10% anyways. I didn't go for any of the bonuses to attributes through perks, for much the same reason - can just get them from books, especially if you save the books for comprehension. That's about 50% bonuses to all attributes.
I am looking forward to Vegas - especially as I've spent more time in the SW than I have around DC (as you sort of alluded to in reverse earlier). I'm going to wait to hear if it's glitchy on the PS3 though. I checked my old guy and the save is about 16mb, which explains why it doesn't play worth a shit anymore. Somewhere along the line I read something about shrinking save files to make them more playable. I might try to track that down, as I'd played through a lot of the game on ol' Iggy Ignatowski, and it was a shame to have to put him on the shelf.